Getting ready to flush my 350 and install all new hoses plus thermostat.

I'd suggest stayin around the 180...the 160 might be ok, but if the engine runs too cool(yeah...like that's gonna happen!), it can create problems with condensation forming on the interior of the block, and the efficiency of the engine will be lower, also.
Actually, running a 160 deg. thermo on our cars really won't do any good, as the temp is always going to be more than that anyway...the only difference is it will open a little sooner than the 180. If you have colder weather year round, the 180 is probably a better choice.

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Joel Adams
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"Money can't buy happiness -- but somehow it's more comforting to cry in a CORVETTE than in a Kia"

I run 180 in mine. Car never goes over 200 but will stay on 180 as long as I am moving. 

Good point guys....

If you are going to flush the whole system, make sure to pull the two plugs on either side of the block to get every thing. You may have to use a screwdriver to break the scale once you remove the plugs though. I did. 

Thanks eddie 70

If you do remove the plugs, buy new ones!! cheap insurance!!But I'm like you. thats not going to happen. I'm to old.

Zgator

Do yourself a favor and address the radiator to hood and side baffels. I was running about 230-240 with my big block. I found some a/c coolant line wrap. The thick black foam and sliced it to fit in all the area around the radiator(top and sides)or buy a set from Ecklers or whoever. That makes a big difference. Also I put in royal purple ICE (great stuff) and installed electric fans. If you have motor driven fans be sure you have the fan ductwork on.I rarely get over 205 now with the norm (driving) at 190-195.

Thanks custom76,

Sounds good. The sealing will help alot. The more air going through instead of around the rad is what you want. I also use Royal Purple Ice which helps out as a water wetter. Makes the water give up the heat better.