My car is a small block, so not sure what would be differnt on a big block. I put the engine and transmission in together. I had the radiator and teh radiator support out, so there was plenty of room to maneuver. I did it in my garage with a 9 foot ceiling. Just make sure you have teh balancing bar to go with the lift. I had everything on the engine except the distributer cover, and fan. There might not be as much room for the big block - not sure on that, but I'll bet othere will chime in.
I should mention that I have a 4 speed tans, but I have a removable transmission crossmember (I think my frame is an auto car donation, but I can't see the vin number on it to verify).
If you have headers, it helps to have them sitting in the car and drop the engine in around them (I have Hooker side pipes).
Something I also learned (actually, had explained to me here) is that if you leave the radiator support out of the car too long, the front end will sag. I had mine out for several months and this happend to me. I got it back in, but there was much swearing and prying involved.
Overall, it wasn't that bad of a job. My dad and I did it in roughly 4 days.